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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
12.42
Human Site:
S748
Identified Species:
27.33
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
S748
H
G
G
V
F
S
Q
S
F
L
P
A
S
D
S
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
S748
H
G
G
V
F
S
Q
S
F
L
P
A
S
D
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
S751
D
E
H
E
G
V
F
S
Q
P
F
L
P
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
S746
R
D
G
V
F
S
Q
S
F
L
P
A
S
D
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
F707
D
G
V
F
S
Q
S
F
L
P
A
T
D
S
D
Chicken
Gallus gallus
XP_421203
1656
188583
S754
G
D
G
V
F
S
H
S
F
L
P
T
T
D
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
A645
E
A
P
P
P
A
L
A
S
S
V
E
W
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
I292
K
S
T
L
R
T
A
I
D
G
G
L
H
E
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
N761
L
E
W
S
S
S
G
N
I
G
L
I
G
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
W403
S
T
S
V
P
Q
F
W
E
P
P
S
D
S
C
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
V726
G
S
G
Y
P
D
I
V
F
E
N
S
S
R
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
13.3
N.A.
86.6
N.A.
N.A.
6.6
66.6
N.A.
0
N.A.
N.A.
0
N.A.
20
P-Site Similarity:
100
100
N.A.
13.3
N.A.
86.6
N.A.
N.A.
6.6
73.3
N.A.
20
N.A.
N.A.
20
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
10
10
0
0
10
28
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
19
19
0
0
0
10
0
0
10
0
0
0
19
46
28
% D
% Glu:
10
19
0
10
0
0
0
0
10
10
0
10
0
10
0
% E
% Phe:
0
0
0
10
37
0
19
10
46
0
10
0
0
0
0
% F
% Gly:
19
28
46
0
10
0
10
0
0
19
10
0
10
0
0
% G
% His:
19
0
10
0
0
0
10
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
0
0
10
10
10
0
0
10
0
0
0
% I
% Lys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
10
0
0
10
0
10
37
10
19
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% N
% Pro:
0
0
10
10
28
0
0
0
0
28
46
0
10
0
0
% P
% Gln:
0
0
0
0
0
19
28
0
10
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% R
% Ser:
10
19
10
10
19
46
10
46
10
10
0
19
37
28
55
% S
% Thr:
0
10
10
0
0
10
0
0
0
0
0
19
10
0
10
% T
% Val:
0
0
10
46
0
10
0
10
0
0
10
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
10
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _